Adam+Myers+LOG

Endogenous alkaloids
 * [You'll have to narrow this down but definitely a good place to start JCB]

//9/1/09-//** What functions does endogenous dimethyltryptamine play in humans. **[Perfect scope JCB]** [|Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine] -sigma 1 receptor regulator -anxiolytic -neurotransmitter at the TA (Trace Amine) system -biosynthesis from tryptophan
 * [wow - that is a really interesting article - I would like to learn more about the TA receptors JCB]**

[|Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor]
 * //9/22/09-//** Researched DMT's activation of the trace amine associated receptor TAAR1

[|The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain] [|The potential of trace amines and their receptors for treating neurological and psychiatric diseases] [|Trace amines: identification of a family of mammalian G protein-coupled receptors] [|Trace amine-associated receptors and their ligands] -TAAR1 is a G protein-coupled receptor activated by trace amines [|Trace amines: Identification of a family of mammalian G protein-coupled receptors] [|Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors] [|Trace amine-associated receptor 1-Family archetype or iconoclast?] -sigma 1 receptor regulator
 * //9/29/09-//** Researched TAAR1 and DMT's role as a sigma 1 receptor regulator
 * [Interesting new article in Nature mentions DMT - see** [|**FF discussion**] **too JCB]**

[|The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain]

 * Trace amines are structurally related compounds found endogenously in the brain and peripheral nervous system of mammals.
 * Metabolicially related to the neurotransmitters norepinephrine, seratonin, and dopamine.
 * Some are synthesized by parent amine neurotransmitter systems, others have their own unique systems.
 * A large amount of research indicates that trace amines coordinate biogenic synaptic physiology.
 * They mimic the presynaptic amphetamine-like effects of biosynthesis, reuptake, and release of catecholamines and indolamines at high concentrations.
 * At low concentrations, they have postsynamptic effects which potentiate the activity of seratonin and dopamine.
 * Trace amine-specific receptors are proven to exist because of their electrophysiological effects that oppose other neurotransmitters.
 * Although several trace amine receptor sites have been studied in detail, their mechanisms of action on indolamine and caecholamine synaptic physiology remains unclear due to the absence of cloned receptor protein.
 * The newly discovered family of G protein-coupled receptors responsive to many trace amines, including illegal psychotropic drugs such as LSD, have prompted research into their synaptic physiology and role in human disorders involving cognition and affect.

11/10/09

5 Properties of //N,N//-Dimethyltryptamine

 * Melting Point**
 * 40–59 ºC [|Wikipedia English]
 * 47–49 ºC [|ChemSynthesis]
 * 49 ºC and 74 ºC (two different crystal structures) [|AllExperts] [|Wikipedia French]
 * 44.6–46.8 ºC [|Wikipedia German]


 * Boiling Point**
 * 332.1 ºC at 760 mmHg [|ChemSpider Predicted]
 * 160 ºC at 0.8 hPa [|AllExperts] [|Wikipedia French][|Wikipedia Netherlands]
 * 60–80 ºC [|Wikipedia German]


 * Density**
 * 1.099 g/cm³ [|ChemSynthesis][|Wikipedia English] [|AllExperts] [|Wikipedia French]
 * 1.076 g/cm³ [|ChemSpider Predicted]


 * LD50**
 * 32 mg/kg (IV) [|ChemCAS] [|Wikipedia German]


 * Partition Coefficient LogP**
 * ACD/LogP: 2.06 [|ChemSpider Predicted]
 * LogP: 1.94 [|NIAID ChemDB]
 * XLogP3: 2.5 [|PubChem]
 * ACD LogP: 2.061[|eMolecules]
 * XLogP: 2.0 [|DMT-Nexus Wiki]


 * 12/3/09-** Finished Research! **[Partial Marks - you don't have 5 different sources for 5 properties - you cannot count different language Wikipedia unless the values differ - use permalink for ChemSpider - convert to common units in addition to the source value JCB]**
 * Exhaustively searched and found every accessible journal article relating to endogenous dimethyltryptamine.
 * Majority of research was done using SciFinder, but
 * **[Beilstein should give you several articles for these properties JCB]**

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