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9/24/09: Project Brainstorm: Some explorations in Oxime compounds as bridging complexes between transition metals. **[Great start - a keyword search on SciFinder should help - try to find a review article if possible JCB]**

10/1/09: Update: I'm pretty bogged down with a Cume for this Saturday, but I did some preliminary searches and found a review or two related to Ni-oxime complexes. My research adviser tells me that nickel complexes are interesting due to the low-spin/high-spin tendencies opening up to multiple conformations (octahedral and square planar). I will likely stick to just nickel-oxime complexes, as there seems to be no dearth of information on the subject.

10/8/09: Fatal Error : I hear that my literature seminar cannot coincide with my project in this class. If that's the case, I may have to focus on something that I'm familiar with from my undergraduate research: perhaps a review of the matrix isolation technique and its importance in studying hydrogen bonding complexes. Should this turn out to be too narrow, I might broaden this to simply a review of the matrix isolation technique, and a few examples of its applications.
 * [matrix isolation techniques is also a good topic - we can discuss it more Thursday if you want JCB]

10/19/09: Assignment Update:   ** I've posted a first edit to the ILL FAQ. Phone interview with Deadra Childs, Hagerty Library ILL supervisor, scheduled for tomorrow to clear up some things. Copy of first edit : **[well done! the interview should clarify the rest JCB]** When a book, journal article, or other form of media is unavailable at Drexel Libraries, students and faculty may use an Interlibrary Loan (ILL) program to obtain the desired materials from other participating colleges and universities. Drexel offers two different ILL services: EZ borrow and ILLiad. The programs require University ID number (EZ borrow) or a Drexel domain username (ILLiad) to enroll, which ensures that that only members associated with Drexel may use the service, as a substantial cost is associated with ILL programs (exact numbers pending interview with Hagerty Library Staff). Also as a result of this cost, only 10 requests may be made by undergraduates, and 20 for graduate students.

The following information is required to obtain an article by ILL: full journal title, year, volume, and pages. Requests are greatly expedited when a DOI or ISBN is included. Requests are usually filled within a week, but some rare materials can take longer. If hard copy materials are ordered, they can be picked up at the library through which the ILL was requested. Most articles, however, are directly emailed to the user for convenience.

EZ Borrow: []. ILLiad: [].

Reference Sources:

[]. []. Answer in Progress by Kyle R. Hess, 10/19/2009 5:35 pm. More information forthcoming.

10/20/09: Project Update:  I've found 5 review articles in the Royal Chemical Society's Annual Reports C (Physical Chemistry) for Matrix Isolation. The contain broad sweeping topics, so I may end up not using all of them, as there are more than 200 references per article. It's a good starting point, and it has a lot of information to help me narrow down my topic. The citations for these articles are listed below, and can be found on the RSC's website.

**//Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 1985, 82, 157 - 191, DOI: 10.1039/PC9858200157//**
 * //Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 1991, 88, 3 - 44, DOI: 10.1039/PC9918800003//**
 * //Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 1997, 93, 3 - 56, DOI: 10.1039/pc093003//**
 * //Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 2001, 97, 3 - 60, DOI: 10.1039/b100090j//**
 * //Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 2007, 103, 79 - 133, DOI: 10.1039/b605697k//**


 * [Do you need help with creating the hyperlinks to the articles? JCB]

//Nah, I know how to do it. I just didn't know we should provide a hyperlink to everything. I saved PDF copies for myself, and knew that I shouldn't put those up. Hyperlinks to the sites have been added.// **

[I wish all the publishers used such a simple way as RSC does to link to DOIs JCB] //I find that I'm biased to RSC journals - I supposed that's a product of working for Dr. Addison! =)// **
 * [Thanks - in general please put a link to the article - at minimum I need it to look at your primary sources - and you might find it helpful as you collect lots of articles and want to quickly find them JCB]


 * 10/23/09: Assignment Update:   ** I've finished my post on ILL. **[Yes that looks complete JCB]** A copy is listed here below. I have also managed to find one of the original papers on the  Matrix Isolation Technique on the Journal of Chemical Physics website. I was led to this citation using google scholar, and believe this is the paper I will complete my synopsis assignment on.

When a book, journal article, or other form of media is unavailable at Drexel Libraries, students and faculty may use an Interlibrary Loan (ILL) program to obtain the desired materials from other participating colleges and universities. Drexel offers two different ILL services: EZ borrow and ILLiad. The programs require University ID number (EZ borrow) or a Drexel domain username (ILLiad) to enroll, which ensures that that only members associated with Drexel may use the service, as a substantial cost is associated with ILL programs. An interview with Peggy Dominy revealed that the cost associated with each transaction is around $29 as of "a couple years ago" - it has likely increased slightly up to this point. Also as a result of this cost, only 10 requests may be made by undergraduates, and 20 for graduate students.

The following information is required to obtain an article by ILL: full journal title, year, volume, and pages. Requests are greatly expedited when a DOI or ISBN is included. Requests are usually filled within a week, but some rare materials can take longer. If hard copy materials are ordered, they can be picked up at the library through which the ILL was requested. Most articles, however, are directly emailed to the user for convenience.

EZ Borrow: []. ILLiad: [].

References: []. [].

10/29/09: Assignment Update: The following is the second part of my assignment - a synopsis on one of the papers being used for my project. The link is here: DOI: 10.1063/1.1739957
 * [Full Marks JCB]**

The goal of the matrix isolation technique is to enable the study of unstable substances, such as intermediates and free radicals. Matrix isolation accomplishes this task by trapping active molecules in a matrix using an inert gas at low temperature and low pressure conditions, which prevent the diffusion of molecules through the matrix, and thus further reaction.

In most cases, the active material is sprayed (gas phase) onto a cold surface where it condenses. So long as a sufficient mole ratio of matrix compound to target compound is used, the matrix will trap the target molecules and even prevent recombination!

Tabel 1 shows the different tests and relative success of each type of matrix material, target (active) material, temperature, and mole ratio.

An intriguing result is obtained when using methane as an active species, and carbon tetrachloride as the matrix species. At 72 K, with a mole ratio of 50:1 matrix:active, it was found that methane was isolated in the matrix EVEN THOUGH methane alone would not be able to condense on the window at this temperature.

Other experiments conducted used either NO2, or hydrogen bonding compounds containing nitrogen. The reason these were chosen is because they all have characteristics such as radical formation and hydrogen bonding that would indicate whether or not isolation was successful.

Xenon has been tested, and although unsuccessful thus far, testing at lower temperatures shows promise (at this time, refridgerants colder than liquid nitrogen were not available).

Matrix isolation was still being developed at this time, and proper mole ratio as well as temperature conditions were needed to do successful studies on free radicals, intermediates, and other unstable compounds.

11/2/09: Updates: I had an idea for which molecule I'm going to do my assignment for, since my project is not molecule specific. I'm going to find the properties of dimethyl mercury. I know already that the toxicity of the compound is extraordinarily high, so if I can't find enough data on it I'll do methyl mercury.
 * [that should work JCB]**

I've also decided that for my project I'll be making a powerpoint slideshow, with myself doing audio to enhance the presentation. I also had a neat idea for a video clip that would fit in perfectly, if I can find the ripping/recording software to do it.
 * [good idea - Camtasia is good for that - that is what I use to record lectures JCB]

11/4/09: Updates: I am having trouble getting data on methyl mercury and dimethyl mercury. I have decided to do hydrocodone instead, as there is a great wealth of information about it. People seem a lot more interested in researching narcotic compounds that will kill you than just compounds that will kill you.

11/9/09: Assignment: I have made a preliminary table of data for Hydrocodone (CAS: 125-29-1). Most of the values were theoretically calculated, since most people work with this compound in MeOH. Note that all values are at STP unless otherwise indicated. **


 * = **Hydrocodone, CAS 125-29-1** ||= Chemspider ||= Pubchem ||= MSDS ||= Drugbank.ca ||= Scifinder ||= Lookchem ||= Lange's Handbook ||= Beilstein #94193 ||
 * = Melting Point (°C) ||= - ||= - ||= - ||= 198 ||= 195 ||= - ||= 197-198 ||= 196.5-197.5 ||
 * = Boiling Point (°C) ||= 461.4 ||= - ||= - ||= - ||= 461.4 ||= 461.4 ||= - ||= - ||
 * = Flash Point (°C) ||= 232.9 ||= - ||= - ||= - ||= 232.9 ||= 232.9 ||= - ||= - ||
 * = Density (g/mL) ||= 1.31 ||= - ||= - ||= - ||= 1.342 ||= 1.31 ||= - ||= 1.342 ||
 * = LD50 (g/kg) ||= - ||= - ||= - ||= - ||= 85.7 (mouse) ||= - ||= - ||= - ||
 * = Enthalpy of Vaporization (kJ/mol) ||= 72.23 ||= - ||= - ||= - ||= 72.23 ||= - ||= - ||= - ||
 * = Vapor Pressure (torr) ||= 1.07E-08 ||= - ||= - ||= - ||= 1.07E-08 ||= - ||= - ||= - ||

Sources that returned no results: NIST, SDBS, Sigma Aldrich, Alfa Aesar, & Fisher Scientific.

__Sources for Scifinder:__

Melting Point: Knoll, A. Chemische Fabriken, Patent No 607931 (this is a patent, and one of the only sources that was Hydrocodone and not a halogenated derivative).

Boiling Point: Calculated using Advanced Chemistry Development (ACD/Labs) Software V8.14 for Solaris (© 1994-2009 ACD/Labs).

Flash Point: Calculated using Advanced Chemistry Development (ACD/Labs) Software V8.14 for Solaris (© 1994-2009 ACD/Labs).

Density: Barnes, W. H.; Canadian Journal of Chemistry 1954, V32, P984-8 CAPLUS. DOI: 10.1139/v54-125

LD50: Milne, G. W. A.; Drugs: Synonyms & Properties 2000, P1280 pp. CAPLUS. Book; ISBN: 0-566-08228-4

Enthalpy of Vaporization: Calculated using Advanced Chemistry Development (ACD/Labs) Software V8.14 for Solaris (© 1994-2009 ACD/Labs).

Vapor Pressure: Calculated using Advanced Chemistry Development (ACD/Labs) Software V8.14 for Solaris (© 1994-2009 ACD/Labs).

__Sources cited by Beilstein Substance #94193:__   Melting Point: Iijima, I. et al. J. Org. Chem.,   **1978**, // 43 // (7), pp 1462–1463 DOI: 10.1021/jo00401a038

Density: Barnes, W. H.; Canadian Journal of Chemistry 1954, V32, P984-8 CAPLUS. DOI: 10.1139/v54-125

__MSDS sheets__ for hydrocodone are only available for Hydrocodone in methanol and a bitartarate derivative.


 * 11/12/09: Assignment: I have come to the conclusion that there's not enough info on this molecule to complete it. I really don't want to remove it, as it makes it would appear that I haven't put forth the effort demanded of the assignment. I'm going to look at TNT, or failing that, something basic like ethanol. **

11/20/09: Assignment: I have constructed a table for dichloromethane (CAS 75-09-2). Unless otherwise noted, measurements were made at STP. The MSDS link doesn't always work for me for some reason - if you have similar trouble, use the Sigma link, and click on MSDS - it will bring you to the one I used. ( Completed: 11/24/09 )


 * =  ||= Wikipedia ||= MSDS ||= Sigma ||= Alfa Aesar ||= NIOSH ||= Chemspider ||= Beilstein ||= Scifinder (predicted) ||= Scifinder (lit) ||= Ref # ||
 * = Refractive Index ||= - ||= - ||= 1.424 ||= 1.4244 ||= - ||= 1.4244 ||= 1.4237 ||= - ||= 1.4241 (20°C) ||= 64 ||
 * = Vapor Pressure (torr) ||= 352.5 ||= 352 (20°C) ||= 353.2 ||= - ||= 350 ||= 350 ||= 435.86 ||= 448 ||= - ||= - ||
 * = Density (g/mL) ||= 1.3266 ||= 1.325 ||= 1.325 ||= 1.325 ||= - ||= - ||= 1.3165 ||= 1.252 ||= 1.326 ||= 12 ||
 * = Metling Point (°C) ||= -96.7 ||= -97 ||= -97 ||= -95 ||= - ||= -95 ||= -96 ||= - ||= -95 ||= 19 ||
 * = Boiling Point (°C) ||= 40 ||= 39.8-40 ||= 40 ||= 39-40 ||= 40 ||= 39-40 ||= 40-41 ||= 39.6 ||= 40 ||= 12 ||
 * = Flash Point (°C) ||= "None" ||= "None" ||= - ||= - ||= "?" ||= "None" ||= - ||= -14.1 ||= - ||= - ||


 * __Beilstein Literature References:__ **

Refractive Index: J. G. Foss, J. A. Schellman: Measurement of Ultraviolet Indices of Refraction with a Differental Refractometer. Journal of Chemical & Engineering Data, **1964** //9// (4), 551-553. DOI: 10.1021/je60023a026

Vapor Pressure: G.J. Price, J.E. Guillet: The Use of Gas Chromatography to Study Solubility in Polymeric Systems. //Journal of Solution Chemistry//, **1987** //16// (6), 605-613. DOI: 10.1007/BF00649087

Density: E. A. Moelwyn-Hughes, R. W. Missen: Thermodynamic Properties of Methyl Iodide and Chloromethane Solutions.**//Trans. Faraday Soc. //**, **1957**, //53// , 607 - 615. DOI: 10.1039/tf9575300607

Melting Point: Richard P. Van Duyne, Charles N. Reilley: Low-temperature Electrochemistry. I. Characteristics of Electrode Reactions in the Absence of Coupled Chemical Kinetics. Analytical Chemistry **1972** //44// (1), 142-152. DOI:10.1021/ac60309a026

Boiling Point: D. Izsák, R. J. W. Le Fèvre: Molecular polarisability. The Apparent Anisotropies of Carbon–halogen Bonds in Methylene Dihalides. <span style="font-family: Arial,Helvetica,sans-serif; font-size: 12px; line-height: 14px;">//J. Chem. Soc. B//, **1966**, 102 - 106. <span style="color: #333333; font-family: Arial,Helvetica,sans-serif; font-size: 12px; line-height: 14px;"> DOI: 10.1039/j29660000102


 * __Scifinder predicted properties:__ ** Advanced Chemistry Development (ACD/Labs) Software V9.04 for Solaris (© 1994-2009 ACD/Labs)


 * __Scifinder Literature References:__ **

12 (Density/Boiling Point): Tian, Ye; Macromolecular Chemistry and Physics 2006, V207(5), P545-553 CAPLUS

19 (Melting Point): D'Hondt, Filip; Chromatographic Science Series 2006, V93(Chromatographic Analysis of the Environment (Third Edition)), P645-665 CAPLUS ISSN: 0069-3936

44 (Flash Point): Kong, Dehong; Journal of Hazardous Materials 2003, V102(2-3), P155-165 CAPLUS DOI: 10.1016/S0304-3894(03)00212-7

64 (Refractive Index): Alexander, D. M.; Journal of Chemical and Engineering Data 1959, V4, P252-4 CAPLUS DOI:10.1021/je60003a016

[Full Marks JCB]
 * DONE

12/3/09: Final Project: I have completed my presentation on Matrix Isolation with some application to inorganic compounds. I will begin recording tomorrow. The presentation is 20 slides long, and I anticipate it will take the better part of 20 minutes to fully speak through. I am planning on making it a two part youtube video with voiceover. I will be using camstudio to record. **

[sounds good - I am not sure if you can save the CamStudio recording in a format that YouTube can take - if you have any trouble try scivee.tv which is what I use for the lectures - that takes FLV format which I think is the default for CamStudio JCB]**